Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 8/20 | 0.93 |
| ▸ | RPS6KB1 | P23443 | 10/20 | 0.72 |
| ▸ | PRKACA | P17612 | 8/20 | 0.72 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.72 |
| ▸ | GSK3B | P49841 | 7/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716563 | 0.98 | RPS6KA5 (0.98) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B | |
| SCHEMBL4714279 | 0.96 | RPS6KA5 (1.00) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B | |
| SCHEMBL4718814 | 0.95 | RPS6KA5 (1.00) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B | |
| SCHEMBL4717447 | 0.88 | RPS6KA5 (1.00) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B | |
| SCHEMBL6405625 | 0.81 | RPS6KB1 (1.00) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B | |
| SCHEMBL6401655 | 0.79 | RPS6KB1 (1.00) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B | |
| SCHEMBL4718787 | 0.78 | RPS6KB1 (0.73) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B | |
| SCHEMBL4714897 | 0.77 | RPS6KB1 (0.69) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B | |
| SCHEMBL4717863 | 0.77 | RPS6KA5 (1.00) | RPS6KA5RPS6KB1ROCK1GSK3BDYRK1A | |
| SCHEMBL4714283 | 0.76 | RPS6KA5 (1.00) | RPS6KA5RPS6KB1PRKACAROCK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |