Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457092 | 0.80 | CHRM2 (0.51) | HTTUSP2HRH3HRH4SMN1; SMN2 | |
| SCHEMBL3457044 | 0.75 | HRH3 (0.51) | HTTUSP2HRH3HRH4SMN1; SMN2 | |
| SCHEMBL3456630 | 0.75 | HRH3 (0.45) | HTTUSP2HRH3HRH4SMN1; SMN2 | |
| SCHEMBL4715354 | 0.75 | USP2 (0.44) | HTTUSP2HRH3HRH4SMN1; SMN2 | |
| SCHEMBL4713979 | 0.74 | SMN1; SMN2 (0.53) | HTTUSP2HRH3HRH4SMN1; SMN2 | |
| SCHEMBL1623822 | 0.73 | NPC1 (0.40) | SMN1; SMN2HDAC1 | |
| SCHEMBL4717200 | 0.73 | CYP1A2 (0.53) | HTTUSP2HRH3HRH4MEN1 | |
| SCHEMBL4420094 | 0.73 | USP2 (0.60) | HTTUSP2HRH3HRH4SMN1; SMN2 | |
| SCHEMBL4714093 | 0.73 | HRH4 (0.40) | HTTUSP2HRH3HRH4SMN1; SMN2 | |
| SCHEMBL3456835 | 0.71 | HRH3 (0.44) | HTTUSP2HRH3HRH4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337517-B1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2008-11-26 | — | — | EP | disclosed |