Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 7/20 | 0.43 |
| ▸ | RAF1 | P04049 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718597 | 0.96 | BRAF (0.46) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4723181 | 0.95 | BRAF (0.45) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4718146 | 0.91 | MEN1 (0.48) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4719574 | 0.91 | MEN1 (0.48) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4719821 | 0.88 | BRAF (0.46) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4718598 | 0.87 | BRAF (0.45) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4717473 | 0.87 | MEN1 (0.51) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4721835 | 0.87 | BRAF (0.53) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4719770 | 0.87 | MEN1 (0.53) | BRAFMEN1NPC1RAB9AKMT2A | |
| SCHEMBL4720600 | 0.87 | MEN1 (0.47) | BRAFMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | claimed |
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| EP-1737462-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060969-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |