Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065544 | 0.91 | SYK (0.48) | SYKKDM4EPOLBRAB9AL3MBTL1 | |
| SCHEMBL4058183 | 0.86 | KDM4E (0.55) | KDM4EPOLBRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL4717608 | 0.84 | SYK (0.47) | SYKKDM4EPOLBRAB9AALDH1A1 | |
| SCHEMBL16110691 | 0.73 | KDM4E (0.55) | KDM4EPOLBRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL8684224 | 0.72 | KDM4E (0.58) | KDM4EPOLBRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL16110055 | 0.70 | KDM4E (0.58) | KDM4EPOLBRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL4063418 | 0.68 | SYK (0.53) | SYKKDM4EPOLBALDH1A1HSD17B10 | |
| SCHEMBL14869429 | 0.67 | CA12 (0.47) | KDM4EPOLBRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL4059538 | 0.66 | SYK (0.43) | SYKPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL16110057 | 0.66 | KDM4E (0.61) | KDM4EPOLBRAB9AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999127-A1 | PHTHALAZINONE PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107298-A1 | PHTHALAZINONE PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |