Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13823637 | 0.77 | NOTUM (0.50) | SLC6A2SLC6A4NOTUMALDH1A1CYP3A4 | |
| SCHEMBL5848884 | 0.72 | SLC6A2 (0.45) | SLC6A2SLC6A4NOTUMALDH1A1CYP3A4 | |
| SCHEMBL13180794 | 0.72 | NOTUM (0.45) | SLC6A2SLC6A4NOTUMALDH1A1CYP3A4 | |
| SCHEMBL13888901 | 0.70 | SLC6A2 (0.78) | SLC6A2SLC6A4 | |
| SCHEMBL2625781 | 0.68 | NOTUM (0.55) | SLC6A2SLC6A4NOTUMCYP3A4CYP2D6 | |
| SCHEMBL22240446 | 0.68 | NOTUM (0.55) | SLC6A2SLC6A4NOTUMCYP3A4CYP2D6 | |
| SCHEMBL18681421 | 0.68 | NOTUM (0.55) | SLC6A2SLC6A4NOTUMCYP3A4CYP2D6 | |
| SCHEMBL13372442 | 0.68 | NOTUM (0.55) | SLC6A2SLC6A4NOTUMCYP3A4CYP2D6 | |
| SCHEMBL14218868 | 0.67 | NOTUM (0.50) | SLC6A2SLC6A4NOTUMALDH1A1ROCK1 | |
| SCHEMBL20467040 | 0.66 | NOTUM (0.41) | SLC6A2SLC6A4NOTUMALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931631-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007041023-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2007-04-12 | — | — | WO | disclosed |