Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717188 | 0.83 | SLC6A2 (0.61) | SLC6A4SLC6A2 | |
| SCHEMBL4717708 | 0.83 | SLC6A2 (0.61) | SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL5473171 | 0.82 | SLC6A2 (0.62) | SLC6A4SLC6A2 | |
| SCHEMBL4717618 | 0.70 | SLC6A2 (0.74) | SLC6A4SLC6A2 | |
| SCHEMBL4081191 | 0.70 | SLC6A4 (0.43) | SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL5483121 | 0.70 | SLC6A2 (0.73) | SLC6A4SLC6A2 | |
| SCHEMBL4081843 | 0.69 | SLC6A2 (0.60) | SLC6A4SLC6A2 | |
| SCHEMBL4718520 | 0.66 | HTR2A (0.40) | KDM4EMEN1KMT2A | |
| SCHEMBL19117686 | 0.64 | CYP2A6 (0.41) | CYP2A6 | |
| SCHEMBL4089981 | 0.62 | SLC6A2 (0.77) | SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931631-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007041023-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2007-04-12 | — | — | WO | disclosed |