Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 16/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 16/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715591 | 1.00 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3PRMT5MEN1 | |
| SCHEMBL4718232 | 0.88 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3PRMT5ALDH1A1 | |
| SCHEMBL4720450 | 0.85 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5475823 | 0.85 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4077127 | 0.84 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL4717577 | 0.84 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5484366 | 0.84 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4718307 | 0.81 | SLC6A2 (0.46) | SLC6A2SLC6A4PRMT5MEN1KMT2A | |
| SCHEMBL4090139 | 0.81 | SLC6A2 (0.71) | SLC6A2SLC6A4MEN1KMT2AALDH1A1 | |
| SCHEMBL4715366 | 0.78 | SLC6A2 (0.44) | SLC6A2SLC6A4PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931631-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007041023-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2007-04-12 | — | — | WO | disclosed |