Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 4/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598575 | 0.87 | HRH3 (0.46) | HRH3MRGPRX4ESRRAARSLC22A12 | |
| SCHEMBL4598015 | 0.76 | KDM4E (0.60) | HRH3MRGPRX4ESRRAARSLC22A12 | |
| SCHEMBL4597712 | 0.75 | HRH3 (0.44) | HRH3ARSLC22A12PPARG | |
| SCHEMBL4598354 | 0.75 | AR (0.49) | HRH3ESRRAARSLC22A12KDM4E | |
| SCHEMBL16483429 | 0.73 | FFAR4 (0.47) | HRH3FFAR4MRGPRX4ARKDM4E | |
| SCHEMBL2229628 | 0.70 | PDE4B (0.42) | HRH3ARPDE4BPDE4APDE4C | |
| SCHEMBL2527265 | 0.69 | KDM4E (0.40) | FFAR4PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4596118 | 0.68 | MAP4K4 (0.51) | KDM4EMAPTMEN1KMT2A | |
| SCHEMBL2532242 | 0.67 | KDM4E (0.42) | HRH3ARPDE4BPDE4APDE4C | |
| SCHEMBL4596740 | 0.67 | MAPT (0.38) | KDM4EMAPTMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |