Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 15/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714617 | 0.89 | RPS6KA5 (1.00) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4716547 | 0.87 | RPS6KA5 (0.77) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4718407 | 0.85 | RPS6KA5 (0.76) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4716310 | 0.85 | RPS6KA5 (0.76) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4717298 | 0.85 | RPS6KA5 (0.76) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4714283 | 0.84 | RPS6KA5 (1.00) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4714200 | 0.83 | RPS6KB1 (0.77) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4714521 | 0.82 | RPS6KA5 (0.71) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4718574 | 0.82 | RPS6KA5 (0.69) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 | |
| SCHEMBL4718298 | 0.80 | RPS6KA5 (0.82) | RPS6KA5DYRK1ARPS6KB1ROCK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |