Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721886 | 0.92 | MAPT (0.61) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4724655 | 0.90 | MAPT (0.65) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4722870 | 0.90 | MAPT (0.58) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4722094 | 0.88 | MAPT (0.58) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4724472 | 0.88 | MAPT (0.59) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4766617 | 0.87 | MAPT (0.69) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4723050 | 0.87 | MAPT (0.66) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4720211 | 0.87 | MAPT (0.62) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4723511 | 0.86 | MAPT (0.64) | MAPTHTTHTR6LMNAKMT2A | |
| SCHEMBL4719171 | 0.86 | MAPT (0.66) | MAPTHTTHTR6LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |