Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 15/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.57 |
| ▸ | AKT1 | P31749 | 7/20 | 0.53 |
| ▸ | AKT2 | P31751 | 7/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | GSK3A | P49840 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.50 |
| ▸ | PRKACA | P17612 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | GRK5 | P34947 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4719685 | 0.99 | RPS6KA5 (0.59) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4716294 | 0.93 | RPS6KA5 (0.56) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL6647884 | 0.90 | ROCK1 (0.54) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4714480 | 0.87 | RPS6KA5 (0.62) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4718533 | 0.87 | RPS6KA5 (0.57) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4719973 | 0.87 | RPS6KA5 (0.57) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4717319 | 0.86 | RPS6KA5 (0.53) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL4714602 | 0.86 | RPS6KA5 (0.61) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4716971 | 0.85 | RPS6KA5 (0.55) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4718805 | 0.84 | RPS6KA5 (0.67) | RPS6KA5ROCK1AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |