Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.49 |
| ▸ | RAF1 | P04049 | 12/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721535 | 0.99 | BRAF (0.48) | BRAFRAF1RETMEN1NPC1 | |
| SCHEMBL4719736 | 0.96 | BRAF (0.51) | BRAFRAF1RETALK | |
| SCHEMBL4719244 | 0.95 | BRAF (0.49) | BRAFRAF1RETALK | |
| SCHEMBL4721876 | 0.94 | BRAF (0.49) | BRAFRAF1RETKDRFLT3 | |
| SCHEMBL4721107 | 0.90 | BRAF (0.51) | BRAFRAF1FLT3 | |
| SCHEMBL4720615 | 0.89 | BRAF (0.51) | BRAFRAF1RETKDRFLT3 | |
| SCHEMBL4716501 | 0.88 | BRAF (0.52) | BRAFRAF1MEN1NPC1RAB9A | |
| SCHEMBL4718146 | 0.88 | MEN1 (0.48) | BRAFRAF1RETMEN1NPC1 | |
| SCHEMBL4719574 | 0.87 | MEN1 (0.48) | BRAFRAF1RETMEN1NPC1 | |
| SCHEMBL4718677 | 0.87 | BRAF (0.51) | BRAFRAF1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | claimed |
| EP-1737462-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060969-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |