Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.59 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720657 | 0.87 | MAPK14 (0.68) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL4715085 | 0.85 | MAPK14 (0.60) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL4717552 | 0.85 | MAPK14 (0.60) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL18407354 | 0.81 | MAPK14 (0.81) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL2959453 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL4718840 | 0.81 | MAPK14 (0.54) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL4718949 | 0.79 | MAPK14 (0.52) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL2951025 | 0.79 | MAPK14 (0.69) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL4717470 | 0.78 | MAPK14 (0.51) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL13234497 | 0.77 | MAPK14 (0.69) | MAPK14MAPK13MAPK11MAPTMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| US-20080027076-A1 | Pyrimidines With Tie2 (Tek) Activity | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027076-A1 | Pyrimidines With Tie2 (Tek) Activity | TIE1, TEK, TEKT1 | MAPK14 3175/4885MAPK13 2573/4885MAPK11 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.