Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 19/20 | 0.70 |
| ▸ | ERBB3 | P21860 | 16/20 | 0.70 |
| ▸ | ERBB4 | Q15303 | 16/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506583 | 0.86 | EGFR (0.79) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL3504977 | 0.85 | EGFR (0.72) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL4720541 | 0.85 | EGFR (0.72) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL2751141 | 0.84 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL2748571 | 0.83 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL3507315 | 0.83 | EGFR (0.76) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL3506589 | 0.83 | EGFR (0.76) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL14494850 | 0.82 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL3506298 | 0.82 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL3508247 | 0.82 | EGFR (0.78) | EGFRERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957495-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064045-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-06-07 | — | — | WO | disclosed |