Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAMP1 | O60894 | 1/20 | 0.49 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | CALCA | P06881 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 5/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718770 | 1.00 | RAMP1 (0.49) | RAMP1CALCRLLRRK2DPP8CHRM1 | |
| Hydrochloric Acid SCHEMBL3306020 | 0.99 | RAMP1 (0.49) | RAMP1CALCRLLRRK2DPP8CHRM1 | |
| SCHEMBL4720819 | 0.97 | RAMP1 (0.50) | RAMP1CALCRLLRRK2DPP8CHRM1 | |
| SCHEMBL5248991 | 0.90 | RAMP1 (0.59) | RAMP1CALCRLDPP8CHRM1ADRB2 | |
| SCHEMBL4720733 | 0.84 | RAMP1 (0.44) | RAMP1CALCRLDPP8ADRB2DPP4 | |
| SCHEMBL13361289 | 0.83 | RAMP1 (0.48) | RAMP1CALCRLDPP8ADRB2DPP4 | |
| SCHEMBL3314750 | 0.81 | RAMP1 (0.59) | RAMP1CALCRLCHRM1ADRB2CALCA | |
| SCHEMBL3314758 | 0.81 | RAMP1 (0.59) | RAMP1CALCRLCHRM1ADRB2CALCA | |
| Trifluoroacetic Acid SCHEMBL7008582 | 0.79 | DPP4 (0.48) | CALCRLDPP8CHRM1ALOX15CYP3A4 | |
| SCHEMBL3960017 | 0.79 | DPP8 (0.47) | CALCRLLRRK2DPP8CHRM1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558600-B1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-05-07 | — | — | EP | claimed |