⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722099 | 0.86 | CHRM2 (0.44) | — | |
| SCHEMBL9035179 | 0.86 | CHRM2 (0.35) | — | |
| SCHEMBL22773777 | 0.85 | CHRM2 (0.42) | — | |
| SCHEMBL845377 | 0.80 | — | — | |
| SCHEMBL202946 | 0.79 | — | — | |
| SCHEMBL9109447 | 0.78 | — | — | |
| SCHEMBL21766160 | 0.76 | — | — | |
| SCHEMBL10305028 | 0.76 | — | — | |
| SCHEMBL11603818 | 0.76 | — | — | |
| SCHEMBL3166958 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022256299-A1 | 7-MORPHOLINO-5-(3-PHENYL-1 H-PYRAZOL-1 -YL)-FURO[3,2-B]PYRIDINE DERIVATIVES AND SIMILAR COMPOUNDS AS PIKFYVE KINASE INHIBITORS FOR THE TREATMENT OF E.G. AMYOTROPHIC LATERAL SCLEROSIS (ALS) | Verge Analytics, Inc. (US) | 2022-12-08 | — | — | WO | claimed |
| CN-104045599-B | The preparation method of 2- amino-3-aryl quinoline | 江西师范大学 | 2019-03-26 | — | — | CN | claimed |
| CN-104045599-A | Preparation method of 2-amino-3-aryl quinoline derivative | UNIV JIANGXI NORMAL | 2014-09-17 | — | — | CN | claimed |
| WO-2022256300-A1 | FUSED BICYCLIC HETEROCYCLIC COMPOUNDS AND USES THEREOF | Verge Analytics, Inc. (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022256299-A1 | 7-MORPHOLINO-5-(3-PHENYL-1 H-PYRAZOL-1 -YL)-FURO[3,2-B]PYRIDINE DERIVATIVES AND SIMILAR COMPOUNDS AS PIKFYVE KINASE INHIBITORS FOR THE TREATMENT OF E.G. AMYOTROPHIC LATERAL SCLEROSIS (ALS) | Verge Analytics, Inc. (US) | 2022-12-08 | — | — | WO | disclosed |
| CN-104045599-B | The preparation method of 2- amino-3-aryl quinoline | 江西师范大学 | 2019-03-26 | — | — | CN | disclosed |
| CN-104045599-A | Preparation method of 2-amino-3-aryl quinoline derivative | UNIV JIANGXI NORMAL | 2014-09-17 | — | — | CN | disclosed |
| CN-102231950-A | Releasable polymeric lipids for nucleic acids delivery systems | ENZON PHARMACEUTICALS INC | 2011-11-02 | — | — | CN | disclosed |
| CN-102215820-A | Releasable Fusogenic Lipids for Nucleic Acid Delivery Systems | ENZON PHARMACEUTICALS INC | 2011-10-12 | — | — | CN | disclosed |
| US-20080200475-A1 | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors | PFIZER INC. | 2008-08-21 | — | — | US | disclosed |
| US-20080194590-A1 | 4-Piperazinylthieno [2,3-D] Pyrimidine Compounds as Platelet Aggregation Inhibitors | PFIZER INC | 2008-08-14 | — | — | US | disclosed |
| WO-2006100591-A1 | 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-09-28 | — | — | WO | disclosed |
| WO-2006079916-A1 | THIENO [2,3-D] PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-08-03 | — | — | WO | disclosed |
| EP-0563328-B1 | Tc(III)-99m MYOCARDIAL IMAGING AGENTS AND METHOD OF USE | MALLINCKRODT MEDICAL INC (US) | 1999-06-30 | — | — | EP | disclosed |
| US-5541289-A | REDUCING A PHOSPHINE SULFIDE TO A PHOSPHINE IN A PEPTIDE | WASHINGTON UNIVERSITY (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0563328-A1 | ?99m Tc(III) MYOCARDIAL IMAGING AGENTS AND METHOD OF USE | MALLINCKRODT MEDICAL, INC. (US) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992011040-A2 | 99mTc(III) MYOCARDIAL IMAGING AGENTS AND METHOD OF USE | MALLINCKRODT MEDICAL, INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| US-5112595-A | Diaminoalkyldifuranones and phosphine ligands with technetium for imaging | MALLINCKRODT MEDICAL, INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5112594-A | Diaminoalkyldifuranones and phosphine ligands with technetium for imaging | MALLINCKRODT MEDICAL, INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-4842638-A | Herbicidal tetrahydro(thio)pyran-2,4-dione derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1989-06-27 | — | — | US | disclosed |