⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3744556 | 0.67 | IDO1 (0.50) | — | |
| SCHEMBL595649 | 0.63 | — | — | |
| SCHEMBL1083825 | 0.63 | — | — | |
| SCHEMBL1822949 | 0.62 | — | — | |
| SCHEMBL1548449 | 0.62 | — | — | |
| SCHEMBL14416088 | 0.62 | — | — | |
| SCHEMBL13670531 | 0.59 | — | — | |
| SCHEMBL4685169 | 0.59 | — | — | |
| SCHEMBL7995627 | 0.57 | — | — | |
| SCHEMBL1999085 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2355 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240317753-A9 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2024-09-26 | — | — | US | claimed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | claimed |
| US-20170260230-A1 | COMPUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS INC (US) | 2017-09-14 | — | — | US | claimed |
| EP-2501236-B1 | N-[2-fluoro-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-benzenesulfonamide derivatives as Raf protein kinase modulators for the treatment of cancer | PLEXXIKON INC (US) | 2017-03-29 | — | — | EP | claimed |
| US-20160083421-A1 | COMPUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS INC (US) | 2016-03-24 | — | — | US | claimed |
| EP-2276767-B1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2014-05-07 | — | — | EP | claimed |
| US-8716322-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2014-05-06 | — | — | US | claimed |
| US-8673928-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2014-03-18 | — | — | US | claimed |
| US-20130130968-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2013-05-23 | — | — | US | claimed |
| EP-1948678-B1 | Compounds for enzyme inhibition | ONYX THERAPEUTICS INC (US) | 2013-05-01 | — | — | EP | claimed |
| EP-1948678-A1 | COMPOUNDS FOR ENZYME INHIBITION | Proteolix, Inc. (US) | 2008-07-30 | — | — | EP | claimed |
| WO-2007056464-A1 | COMPOUNDS FOR ENZYME INHIBITION | PROTEOLIX, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| US-20070105786-A1 | Peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases, e.g., the chymotrypsin-like activity of the 20S proteasome; antiproliferative and antiinflammatory agents | PROTEOLIX, INC. (US) | 2007-05-10 | — | — | US | claimed |
| US-20070088044-A1 | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB | 2007-04-19 | — | — | US | claimed |
| EP-0569333-B1 | Novel N-aralkyl and N-heteroaralkylamino alcane phosphinic acids | NOVARTIS AG (CH) | 1999-01-07 | — | — | EP | claimed |
| EP-0477197-B1 | PREPARATION OF 2-(2-TRITYLAMINOTHIAZOL-4-YL)-2-SYN-METHOXYIMINOACETIC ACID | UPJOHN CO (US) | 1995-07-12 | — | — | EP | claimed |
| US-5424441-A | Nootropic, antiepileptic agents | CIBA-GEIGY CORPORATION (US) | 1995-06-13 | — | — | US | claimed |
| EP-0569333-A2 | Novel N-aralkyl and N-heteroaralkylamino alcane phosphinic acids | CIBA-GEIGY AG (CH) | 1993-11-10 | — | — | EP | claimed |
| EP-0477197-A1 | PREPARATION OF 2-(2-TRITYLAMINOTHIAZOL-4-YL)-2-SYN-METHOXYIMINOACETIC ACID. | UPJOHN CO (US) | 1992-04-01 | — | — | EP | claimed |
| WO-1990015802-A1 | PREPARATION OF 2-(2-TRITYLAMINOTHIAZOL-4-YL)-2-SYN-METHOXYIMINOACETIC ACID | THE UPJOHN COMPANY (US) | 1990-12-27 | — | — | WO | claimed |