Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719231 | 0.94 | POLB (0.48) | POLBMAPTSMN1; SMN2CNR1CNR2 | |
| SCHEMBL6251041 | 0.82 | POLB (0.53) | POLBMAPTSMN1; SMN2 | |
| SCHEMBL27758481 | 0.82 | CNR2 (0.37) | POLBMAPTSMN1; SMN2CNR1CNR2 | |
| SCHEMBL1406899 | 0.79 | POLB (0.47) | POLBMAPTSMN1; SMN2HCAR3KDM4C | |
| SCHEMBL23039053 | 0.79 | POLB (0.47) | POLBMAPTSMN1; SMN2 | |
| SCHEMBL4717605 | 0.78 | KDM4E (0.47) | POLBMAPTSMN1; SMN2 | |
| SCHEMBL1407135 | 0.77 | MAPT (0.45) | POLBMAPTSMN1; SMN2 | |
| SCHEMBL7811465 | 0.77 | MAPK14 (0.43) | — | |
| SCHEMBL31319669 | 0.77 | TLR8 (0.40) | — | |
| SCHEMBL26123653 | 0.77 | POLB (0.50) | POLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |