Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723319 | 0.93 | MAPT (0.39) | MAPTIMPDH2SMN1; SMN2USP2MAPK1 | |
| SCHEMBL4723560 | 0.93 | MAPT (0.39) | MAPTIMPDH2SMN1; SMN2USP2MAPK1 | |
| SCHEMBL4721816 | 0.92 | MAPT (0.38) | MAPTIMPDH2SMN1; SMN2USP2MAPK1 | |
| SCHEMBL4721750 | 0.91 | PDE4A (0.38) | MAPTIMPDH2SMN1; SMN2USP2MAPK1 | |
| SCHEMBL4723141 | 0.91 | MAPT (0.39) | MAPTIMPDH2SMN1; SMN2USP2MAPK1 | |
| SCHEMBL4722711 | 0.90 | MAPT (0.37) | MAPTIMPDH2P2RY1NPSR1NAMPT | |
| SCHEMBL4724113 | 0.90 | MAPT (0.37) | MAPTIMPDH2SMN1; SMN2USP2MAPK1 | |
| SCHEMBL4720892 | 0.89 | MAPT (0.36) | MAPTIMPDH2MAPK1P2RY1NPSR1 | |
| SCHEMBL4723402 | 0.88 | MAPT (0.38) | MAPTIMPDH2SMN1; SMN2MAPK1HPGD | |
| SCHEMBL4719136 | 0.87 | MAPT (0.37) | MAPTIMPDH2SMN1; SMN2USP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |