Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.59 |
| ▸ | PLK4 | O00444 | 3/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | AXL | P30530 | 3/20 | 0.53 |
| ▸ | FLT4 | P35916 | 3/20 | 0.53 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.53 |
| ▸ | NEK4 | P51957 | 3/20 | 0.53 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.53 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.53 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | BLK | P51451 | 2/20 | 0.53 |
| ▸ | STK3 | Q13188 | 2/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5477222 | 0.90 | KDR (0.55) | KDRPLK4MAP4K4LCKAXL | |
| SCHEMBL5472376 | 0.87 | KDR (0.76) | KDRPLK4MAP4K4LCKAXL | |
| SCHEMBL5468985 | 0.84 | KDR (0.59) | KDRPLK4MAP4K4LCKAXL | |
| SCHEMBL4719687 | 0.82 | MAP4K4 (0.78) | KDRPLK4MAP4K4LCKAXL | |
| SCHEMBL4762288 | 0.77 | KDR (0.75) | KDRPLK4MAP4K4LCKAXL | |
| SCHEMBL3529742 | 0.76 | KDR (0.79) | KDRPLK4MAP4K4LCKAXL | |
| SCHEMBL3531078 | 0.74 | KDR (1.00) | KDRPLK4MAP4K4LCKAXL | |
| SCHEMBL3529396 | 0.73 | KDR (0.68) | KDRPLK4MAP4K4LCKAXL | |
| SCHEMBL27803825 | 0.73 | NPC1 (0.53) | KDRPNLIPPRKCIPGRALDH1A1 | |
| SCHEMBL4720138 | 0.72 | KDR (0.82) | KDRPLK4MAP4K4LCKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101336244-A | 9-membered heterobicyclic compounds useful as protein kinase inhibitors | ABBOTT LAB (US) | 2008-12-31 | — | — | CN | disclosed |
| EP-1968979-A2 | 9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007067781-A2 | 9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2007-06-14 | — | — | WO | disclosed |
| US-20070135387-A1 | Inhibitors of protein kinases | ABBOTT LABORATORIES | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135387-A1 | Inhibitors of protein kinases | MAP3K20, PACSIN2, MAP4K2 | KDR 2196/4885PLK4 230/4885MAP4K4 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.