Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.83 |
| ▸ | HTT | P42858 | 3/20 | 0.83 |
| ▸ | HTR6 | P50406 | 1/20 | 0.83 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723139 | 0.99 | MAPT (0.82) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL2481272 | 0.91 | MAPT (1.00) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL4722922 | 0.90 | MAPT (0.68) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL4721380 | 0.90 | MAPT (0.71) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL4721650 | 0.89 | MAPT (0.76) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL4719322 | 0.88 | MAPT (0.69) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL4722514 | 0.88 | MAPT (0.74) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL4720330 | 0.87 | MAPT (0.68) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL4720638 | 0.87 | MAPT (0.65) | MAPTHTTHTR6NPSR1MAPK1 | |
| SCHEMBL4719534 | 0.87 | MAPT (0.75) | MAPTHTTHTR6NPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |