Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 20/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 10/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 9/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | LYN | P07948 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | CSK | P41240 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3508119 | 0.86 | EGFR (0.79) | EGFRERBB2ERBB4ERBB3LCK | |
| Hydrochloric Acid SCHEMBL3504260 | 0.86 | EGFR (0.78) | EGFRERBB2ERBB4ERBB3LCK | |
| Hydrochloric Acid SCHEMBL3505403 | 0.85 | EGFR (0.62) | EGFRERBB2ERBB4ERBB3 | |
| SCHEMBL3507457 | 0.82 | EGFR (0.60) | EGFRERBB2ERBB4ERBB3LCK | |
| SCHEMBL13226167 | 0.79 | EGFR (0.67) | EGFRERBB2ERBB4ERBB3LCK | |
| Hydrochloric Acid SCHEMBL3505003 | 0.78 | EGFR (0.66) | EGFRERBB2ERBB4ERBB3LCK | |
| SCHEMBL3506986 | 0.78 | EGFR (0.61) | EGFRERBB2ERBB4ERBB3 | |
| Hydrochloric Acid SCHEMBL3506629 | 0.78 | EGFR (0.50) | EGFRERBB2ERBB4ERBB3LCK | |
| SCHEMBL3506229 | 0.76 | EGFR (1.00) | EGFRERBB2ERBB4ERBB3LCK | |
| SCHEMBL3510356 | 0.75 | EGFR (0.77) | EGFRERBB2ERBB4ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957495-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-08-20 | — | — | EP | claimed |
| WO-2007064045-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-06-07 | — | — | WO | claimed |