Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 5/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.59 |
| ▸ | CDK1 | P06493 | 5/20 | 0.59 |
| ▸ | MARK3 | P27448 | 5/20 | 0.59 |
| ▸ | AXL | P30530 | 5/20 | 0.59 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.59 |
| ▸ | STK3 | Q13188 | 5/20 | 0.59 |
| ▸ | MINK1 | Q8N4C8 | 5/20 | 0.59 |
| ▸ | BRSK1 | Q8TDC3 | 5/20 | 0.59 |
| ▸ | SLK | Q9H2G2 | 5/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.59 |
| ▸ | MARK2 | Q7KZI7 | 4/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.59 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.59 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.59 |
| ▸ | MELK | Q14680 | 3/20 | 0.59 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.59 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723212 | 0.89 | PLK4 (0.73) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL5474509 | 0.89 | AURKA (0.63) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL4720107 | 0.89 | MAP4K4 (0.74) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL5472351 | 0.87 | PLK4 (0.78) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL5472205 | 0.80 | MAP4K4 (0.76) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL5474679 | 0.79 | MAP4K4 (0.77) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL4719496 | 0.79 | PLK4 (0.76) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL4721372 | 0.78 | PLK4 (0.89) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL5472182 | 0.77 | STK3 (0.73) | PLK4MAP4K4CDK1MARK3AXL | |
| SCHEMBL546405 | 0.77 | AURKA (0.79) | PLK4MARK2JAK3EGFRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968979-A2 | 9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007067781-A2 | 9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2007-06-14 | — | — | WO | disclosed |
| US-20070135387-A1 | Inhibitors of protein kinases | ABBOTT LABORATORIES | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135387-A1 | Inhibitors of protein kinases | MAP3K20, PACSIN2, MAP4K2 | PLK4 230/4885MAP4K4 31/4885CDK1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.