Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344181 | 1.00 | HSD17B10 (0.36) | HSD17B10ALDH1A1TP53MAPK1IDO1 | |
| SCHEMBL3341438 | 0.91 | HSD17B10 (0.36) | HSD17B10ALDH1A1TP53MAPK1IDO1 | |
| SCHEMBL3342801 | 0.90 | HSD17B10 (0.38) | HSD17B10ALDH1A1TP53MAPK1IDO1 | |
| SCHEMBL3343190 | 0.84 | HSD17B10 (0.36) | HSD17B10ALDH1A1TP53MAPK1ALOX15 | |
| SCHEMBL3342838 | 0.84 | HSD17B10 (0.39) | HSD17B10ALDH1A1TP53MAPK1ALOX15 | |
| SCHEMBL5645863 | 0.83 | HSD17B10 (0.36) | HSD17B10ALDH1A1TP53MAPK1ALOX15 | |
| SCHEMBL3342821 | 0.82 | TP53 (0.43) | HSD17B10ALDH1A1TP53MAPK1IDO1 | |
| SCHEMBL3346668 | 0.80 | MC4R (0.37) | HSD17B10ALDH1A1TP53ALOX15MAPT | |
| SCHEMBL3343838 | 0.77 | HSD17B10 (0.37) | HSD17B10ALDH1A1TP53MAPK1IDO1 | |
| SCHEMBL3344114 | 0.76 | TP53 (0.35) | HSD17B10ALDH1A1TP53MAPK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996202-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104933-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |