Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.64 |
| ▸ | KIT | P10721 | 4/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | LDLR | P01130 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949693 | 0.89 | MAPK14 (0.62) | MAPK14KITLCKSRCLDLR | |
| SCHEMBL2943393 | 0.86 | MAPK14 (0.60) | MAPK14KITLCKSRCLDLR | |
| SCHEMBL10321528 | 0.86 | KIT (0.64) | MAPK14KITMAPK11 | |
| SCHEMBL13234997 | 0.85 | LDLR (0.67) | MAPK14KITLCKSRCLDLR | |
| SCHEMBL2951658 | 0.82 | LDLR (0.66) | MAPK14KITLCKSRCLDLR | |
| SCHEMBL2943844 | 0.81 | KIT (0.82) | MAPK14KITLCKSRCLDLR | |
| SCHEMBL2951060 | 0.79 | KIT (0.79) | MAPK14KITLCKSRCLDLR | |
| SCHEMBL2952365 | 0.79 | KIT (1.00) | MAPK14KITLCKSRCLDLR | |
| SCHEMBL31004385 | 0.79 | KIT (1.00) | MAPK14KITLCKSRCLDLR | |
| SCHEMBL2941807 | 0.78 | KIT (0.82) | MAPK14KITLCKSRCLDLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928844-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007022380-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-02-22 | — | — | WO | claimed |
| EP-1928844-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007022380-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-02-22 | — | — | WO | disclosed |