Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.72 |
| ▸ | PLK1 | P53350 | 2/20 | 0.72 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | CTRC | Q99895 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | GLB1 | P16278 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | SNCA | P37840 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474682 | 1.00 | PLK4 (0.72) | PLK4PLK1LRRK2PDGFRBRET | |
| SCHEMBL5474689 | 1.00 | PLK4 (0.72) | PLK4PLK1LRRK2PDGFRBRET | |
| SCHEMBL14092524 | 0.91 | PLK4 (0.60) | PLK4PLK1LRRK2PDGFRBRET | |
| SCHEMBL29443853 | 0.88 | LRRK2 (0.65) | PLK4PLK1LRRK2 | |
| SCHEMBL8205160 | 0.88 | LRRK2 (0.65) | PLK4PLK1LRRK2 | |
| SCHEMBL250593 | 0.88 | LRRK2 (0.65) | PLK4PLK1LRRK2 | |
| SCHEMBL250592 | 0.88 | LRRK2 (0.65) | PLK4PLK1LRRK2 | |
| Tert-Butyl Formate SCHEMBL27796204 | 0.88 | PLK4 (0.60) | PLK4PLK1LRRK2PDGFRBKDR | |
| SCHEMBL1973434 | 0.84 | PDGFRB (0.72) | PLK4PLK1LRRK2PDGFRBRET | |
| SCHEMBL12580650 | 0.84 | PDGFRB (0.72) | PLK4PLK1LRRK2PDGFRBRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038543-A1 | ANTI-GLYCATION PROPERTIES OF OXINDOLE DERIVATIVES | CHOUDHARY MUHAMMAD IQBAL (PK) | 2015-02-05 | — | — | US | claimed |
| US-20150038543-A1 | ANTI-GLYCATION PROPERTIES OF OXINDOLE DERIVATIVES | CHOUDHARY MUHAMMAD IQBAL (PK) | 2015-02-05 | — | — | US | disclosed |
| US-7495007-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-02-24 | — | — | US | disclosed |
| EP-1996590-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-la Roche AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| US-20080009486-A1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-01-10 | — | — | US | disclosed |
| WO-2007104664-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-20 | — | — | WO | disclosed |
| WO-2007104664-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-20 | — | — | WO | disclosed |
| US-20070213341-A1 | Spiroindolinone derivatives | CHEN LI | 2007-09-13 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009486-A1 | SPIROINDOLINONE DERIVATIVES | RB1, PKD1, KRAS | PLK4 447/4885PLK1 810/4885LRRK2 234/4885 |
| US-20070213341-A1 | Spiroindolinone derivatives | MKI67, PKD1, RCC2 | PLK4 312/4885PLK1 545/4885LRRK2 1233/4885 |
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | PLK4 3502/4885PLK1 1202/4885LRRK2 1753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.