Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522241 | 1.00 | EGFR (0.63) | EGFRERBB2ERBB4EPHA2KDR | |
| SCHEMBL3525104 | 1.00 | EGFR (0.63) | EGFRERBB2ERBB4EPHA2KDR | |
| SCHEMBL4732808 | 0.93 | EGFR (0.60) | EGFRERBB2ERBB4 | |
| SCHEMBL3523179 | 0.93 | EGFR (0.60) | EGFRERBB2ERBB4 | |
| SCHEMBL3525388 | 0.93 | EGFR (0.60) | EGFRERBB2ERBB4 | |
| SCHEMBL3523105 | 0.93 | EGFR (0.60) | EGFRERBB2ERBB4 | |
| SCHEMBL3519725 | 0.93 | EGFR (0.60) | EGFRERBB2ERBB4 | |
| SCHEMBL3525278 | 0.92 | EGFR (0.57) | EGFRERBB2ERBB4 | |
| SCHEMBL3525687 | 0.92 | EGFR (0.57) | EGFRERBB2ERBB4 | |
| SCHEMBL13499955 | 0.92 | EGFR (0.52) | EGFRERBB2EPHA2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622620-B1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| EP-1622620-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096226-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | disclosed |