Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343950 | 0.95 | MEN1 (0.50) | MAPTTHRBTP53ALDH1A1KDM4E | |
| SCHEMBL1345713 | 0.95 | MAPT (0.56) | MAPTTHRBTP53POLBMEN1 | |
| SCHEMBL1344310 | 0.88 | MAPT (0.48) | MAPTTHRBTP53POLBMEN1 | |
| SCHEMBL1346850 | 0.87 | MEN1 (0.52) | MAPTTHRBPOLBMEN1KMT2A | |
| SCHEMBL1344134 | 0.86 | MAPT (0.49) | MAPTTHRBTP53ALDH1A1POLB | |
| SCHEMBL1346103 | 0.85 | MAPT (0.49) | MAPTTHRBTP53POLBHPGD | |
| SCHEMBL1347619 | 0.85 | MAPT (0.48) | MAPTTHRBTP53ALDH1A1POLB | |
| SCHEMBL1346948 | 0.84 | MAPT (0.48) | MAPTTHRBTP53ALDH1A1POLB | |
| SCHEMBL1345469 | 0.84 | MAPT (0.48) | MAPTTHRBTP53POLBHPGD | |
| SCHEMBL1345985 | 0.83 | MAPT (0.47) | MAPTTHRBTP53POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016676-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | claimed |