Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727611 | 0.88 | ABL1 (0.51) | ABL1CSF1RFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL4725333 | 0.87 | ABL1 (0.50) | ABL1CSF1RFGFR1FLT1FLT4 | |
| SCHEMBL4730317 | 0.87 | KDR (0.51) | ABL1CSF1RFGFR1FLT1FLT4 | |
| SCHEMBL4726551 | 0.87 | KDR (0.51) | ABL1CSF1RFGFR1FLT1FLT4 | |
| SCHEMBL4726825 | 0.85 | CA1 (0.52) | ABL1CSF1RFGFR1FLT1FLT4 | |
| SCHEMBL4730202 | 0.84 | NPC1 (0.51) | ABL1CSF1RFGFR1FLT1FLT4 | |
| SCHEMBL4725913 | 0.84 | RXFP1 (0.53) | ABL1CSF1RFGFR1FLT1FLT4 | |
| SCHEMBL4725360 | 0.84 | POLB (0.50) | ABL1CSF1RFGFR1FLT1FLT4 | |
| SCHEMBL4725101 | 0.84 | MEN1 (0.55) | ABL1CSF1RFGFR1FLT1FLT4 | |
| SCHEMBL4725980 | 0.84 | ABL1 (0.49) | ABL1CSF1RFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021725-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-21 | — | — | WO | claimed |
| WO-2008021725-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |