Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.42 |
| ▸ | BRAF | P15056 | 14/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729551 | 0.93 | RAF1 (0.41) | RAF1BRAFTEKTRPV1EPHX2 | |
| SCHEMBL4727578 | 0.93 | RAF1 (0.41) | RAF1BRAFTEKTRPV1EPHX2 | |
| SCHEMBL4728339 | 0.92 | RAF1 (0.43) | RAF1BRAFTEKTRPV1EPHX2 | |
| SCHEMBL4728378 | 0.91 | RAF1 (0.47) | RAF1BRAFTEK | |
| SCHEMBL4728250 | 0.90 | MAPK14 (0.42) | RAF1BRAFTRPV1EPHX2 | |
| SCHEMBL4728324 | 0.88 | EGFR (0.48) | RAF1BRAFTEKTRPV1EPHX2 | |
| SCHEMBL4725070 | 0.88 | TEK (0.46) | RAF1BRAFTEKTRPV1 | |
| SCHEMBL4730006 | 0.88 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL4731673 | 0.88 | RAF1 (0.41) | RAF1BRAFTEK | |
| SCHEMBL4727412 | 0.88 | RAF1 (0.43) | RAF1BRAFTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |