Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779920 | 0.95 | EGFR (0.67) | EGFRIGF1RNPC1MAPTMAPK1 | |
| SCHEMBL4726567 | 0.94 | MEN1 (0.57) | EGFRIGF1RNPC1MAPTMAPK1 | |
| SCHEMBL4725213 | 0.88 | IGF1R (0.55) | EGFRIGF1RAURKACDK2KDR | |
| SCHEMBL4725764 | 0.87 | AURKA (0.51) | EGFRAURKANPC1MAPTMAPK1 | |
| SCHEMBL4728512 | 0.87 | EGFR (0.58) | EGFRIGF1RAURKACDK2KDR | |
| SCHEMBL4728074 | 0.82 | EGFR (0.58) | EGFRIGF1RAURKANPC1MAPT | |
| SCHEMBL4727466 | 0.81 | AURKA (0.52) | EGFRAURKANPC1MAPK1RAB9A | |
| SCHEMBL4779934 | 0.81 | AURKA (0.52) | AURKANPC1MAPTMAPK1RAB9A | |
| SCHEMBL4777633 | 0.81 | CLK4 (0.41) | EGFRMAPTMAPK1ALDH1A1LMNA | |
| SCHEMBL4726184 | 0.81 | CDK2 (0.44) | EGFRAURKAMAPK1CDK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |