Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 15/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 3/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2942584 | 0.80 | FYN (0.59) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL2948083 | 0.79 | FYN (0.61) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL103491 | 0.78 | FYN (0.67) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL1050875 | 0.77 | FYN (0.55) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL18613738 | 0.76 | FYN (1.00) | FYN | |
| SCHEMBL102650 | 0.76 | DYRK1A (0.76) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL2944991 | 0.75 | FYN (0.68) | FYNMKNK1 | |
| SCHEMBL18613456 | 0.74 | FYN (1.00) | FYN | |
| SCHEMBL2950361 | 0.74 | FYN (0.58) | FYNDYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL16331300 | 0.72 | FYN (0.66) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025822-A1 | DIAZOLODIAZINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |