SCHEMBL4729593

SCHEMBL4729593

O=C(NO)c1cnc(NC2(c3cccc(F)c3)CCCCC2)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 20/20 1.00
HDAC1 Q13547 20/20 1.00
HDAC2 Q92769 20/20 1.00
HDAC6 Q9UBN7 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29412232 1.00 HDAC3 (1.00) HDAC3HDAC1HDAC2HDAC6
SCHEMBL4729915 0.99 HDAC3 (1.00) HDAC3HDAC1HDAC2HDAC6
SCHEMBL4729535 0.94 HDAC3 (1.00) HDAC3HDAC1HDAC2HDAC6
SCHEMBL4730088 0.89 HDAC3 (1.00) HDAC3HDAC1HDAC2HDAC6
SCHEMBL28067236 0.88 HDAC3 (0.79) HDAC3HDAC1HDAC2HDAC6
SCHEMBL16677851 0.88 HDAC3 (1.00) HDAC3HDAC1HDAC2HDAC6
SCHEMBL18742647 0.86 HDAC3 (0.78) HDAC3HDAC1HDAC2HDAC6
SCHEMBL18822437 0.86 HDAC3 (0.89) HDAC3HDAC1HDAC2HDAC6
SCHEMBL16677938 0.86 HDAC3 (1.00) HDAC3HDAC1HDAC2HDAC6
SCHEMBL8739601 0.86 HDAC3 (1.00) HDAC3HDAC1HDAC2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016120432-A1 COMPOUNDS AND METHODS FOR ANTICOAGULATION THERAPY FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) 2016-08-04 WO claimed
US-20260021093-A1 COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND IMMUNOMODULATORY DRUGS ACETYLON ACQUISITION CORP LLC (US) 2026-01-22 US disclosed
EP-4601630-A1 SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FOR TREATMENT OF LEPTIN-RESISTANT OBESITY The Children's Medical Center Corporation (US) 2025-08-20 EP disclosed
US-20250213561-A1 SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FOR TREATMENT OF LEPTIN-RESISTANT OBESITY THE GENERAL HOSPITAL CORPORATION 2025-07-03 US disclosed
US-20240252496-A1 SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FORTREATMENT OF LEPTIN-RESISTANT OBESITY THE GENERAL HOSPITAL CORPORATION 2024-08-01 US disclosed
US-20240139187-A1 SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FOR TREATMENT OF LEPTIN-RESISTANT OBESITY THE GENERAL HOSPITAL CORPORATION 2024-05-02 US disclosed
WO-2024081587-A1 SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FOR TREATMENT OF LEPTIN-RESISTANT OBESITY THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2024-04-18 WO disclosed
EP-3468559-B1 METHODS OF USE AND PHARMACEUTICAL COMBINATIONS OF HDAC INHIBITORS WITH BET INHIBITORS DANA FARBER CANCER INST INC (US) 2023-11-22 EP disclosed
EP-3468559-B1 METHODS OF USE AND PHARMACEUTICAL COMBINATIONS OF HDAC INHIBITORS WITH BET INHIBITORS DANA FARBER CANCER INST INC (US) 2023-11-22 EP disclosed
US-20230364083-A1 HISTONE DEACETYLASE 6 (HDAC6) BIOMARKERS IN MULTIPLE MYELOMA ACETYLON PHARMACEUTICALS, INC. 2023-11-16 US disclosed
US-20150099744-A1 COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND EITHER HER2 INHIBITORS OR PI3K INHIBITORS ACETYLON PHARMACEUTICALS, INC. (US) 2015-04-09 US disclosed
US-20150099744-A1 COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND EITHER HER2 INHIBITORS OR PI3K INHIBITORS ACETYLON PHARMACEUTICALS, INC. (US) 2015-04-09 US disclosed
WO-2014197471-A1 HISTONE DEACETYLASE ( HDAC) BIOMARKERS IN MULTIPLE MYELOMA ACETYLON PHARMACEUTICALS, INC. (US) 2014-12-11 WO disclosed
WO-2014197471-A1 HISTONE DEACETYLASE ( HDAC) BIOMARKERS IN MULTIPLE MYELOMA ACETYLON PHARMACEUTICALS, INC. (US) 2014-12-11 WO disclosed
US-20140357512-A1 HISTONE DEACETYLASE (HDAC) BIOMARKERS IN MULTIPLE MYELOMA ACETYLON PHARMACEUTICALS, INC. (US) 2014-12-04 US disclosed
US-20140357512-A1 HISTONE DEACETYLASE (HDAC) BIOMARKERS IN MULTIPLE MYELOMA ACETYLON PHARMACEUTICALS, INC. (US) 2014-12-04 US disclosed
US-20140357512-A1 HISTONE DEACETYLASE (HDAC) BIOMARKERS IN MULTIPLE MYELOMA ACETYLON PHARMACEUTICALS, INC. (US) 2014-12-04 US disclosed
US-20140142104-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF ACETYLON PHARMACEUTICALS, INC. 2014-05-22 US disclosed
WO-2012068109-A2 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF ACETYLON PHARMACEUTICALS (US) 2012-05-24 WO disclosed
US-20120121502-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF ACETYLON PHARMACEUTICALS (US) 2012-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250213561-A1 SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FOR TREATMENT OF LEPTIN-RESISTANT OBESITY HDAC6, HDAC3, HDAC1 HDAC3 2/4885HDAC1 3/4885HDAC2 5/4885
US-20240252496-A1 SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FORTREATMENT OF LEPTIN-RESISTANT OBESITY HDAC6, HDAC3, HDAC1 HDAC3 2/4885HDAC1 3/4885HDAC2 5/4885
US-20230364083-A1 HISTONE DEACETYLASE 6 (HDAC6) BIOMARKERS IN MULTIPLE MYELOMA HDAC5, HDAC6, HDAC9 HDAC3 8/4885HDAC1 7/4885HDAC2 6/4885
US-20140142104-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF HDAC6, HDAC1, HDAC5 HDAC3 8/4885HDAC1 2/4885HDAC2 5/4885
US-20150099744-A1 COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND EITHER HER2 INHIBITORS OR PI3K INHIBITORS HDAC6, HDAC2, HDAC5 HDAC3 7/4885HDAC1 6/4885HDAC2 2/4885
US-20120121502-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF HDAC6, HDAC1, HDAC5 HDAC3 8/4885HDAC1 2/4885HDAC2 5/4885
US-20240139187-A1 SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FOR TREATMENT OF LEPTIN-RESISTANT OBESITY HDAC6, HDAC3, HDAC1 HDAC3 2/4885HDAC1 3/4885HDAC2 5/4885
US-20260021093-A1 COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND IMMUNOMODULATORY DRUGS HDAC9, HDAC6, HDAC5 HDAC3 7/4885HDAC1 9/4885HDAC2 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.