Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 16/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL472977 | 0.87 | SCD (0.47) | SCDSCD5 | |
| SCHEMBL473027 | 0.86 | SCD (0.46) | SCDSCD5 | |
| SCHEMBL473006 | 0.86 | SCD (0.46) | SCDSCD5 | |
| SCHEMBL473074 | 0.84 | SCD (0.54) | SCDSCD5 | |
| SCHEMBL368859 | 0.78 | SCD (0.55) | SCDSCD5 | |
| SCHEMBL3591972 | 0.78 | SCD (0.76) | SCDSCD5 | |
| SCHEMBL472993 | 0.77 | SCD (0.55) | SCDSCD5 | |
| SCHEMBL27787023 | 0.77 | SCD (0.46) | SCDSCD5 | |
| SCHEMBL27787024 | 0.77 | SCD (0.45) | SCDSCD5 | |
| SCHEMBL472997 | 0.77 | SCD (0.53) | SCDSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099793-B1 | AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK CANADA INC (CA) | 2012-02-01 | — | — | EP | disclosed |
| US-8063224-B2 | [5-(5-{4-[2-(Trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)-2H-tetrazol-2-yl]acetic acid; metabolic disorders,antidiabetic, hypoglycemic agent; obesity, insulin resistance, liver steatosis, atherosclerosis, neurological disease, dyslipidemia, hyperlipidemia, low HDL, and high LDL | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |