SCHEMBL4730203

SCHEMBL4730203

CCOCc1c(O)c([N+](=O)[O-])cc2c(NCc3ccc(OC)c(Cl)c3)ncnc12

nearest known ligand 0.77

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PDE11A Q9HCR9 10/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4726024 0.88 PDE11A (0.55) PDE11A
SCHEMBL4727805 0.87 PDE11A (0.63) PDE11A
SCHEMBL4780205 0.87 PDE11A (0.54) PDE11A
SCHEMBL4726008 0.82 PDE11A (0.59) PDE11A
SCHEMBL4729881 0.82 PDE11A (0.71) PDE11A
SCHEMBL4725805 0.80 PDE11A (0.58) PDE11A
SCHEMBL4726006 0.79 PDE11A (0.69) PDE11A
SCHEMBL4728689 0.79 PDE5A (0.55) PDE11A
SCHEMBL4726283 0.79 PDE11A (0.56) PDE11A
SCHEMBL4727323 0.78 PDE11A (0.64) PDE11A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008020711-A1 QUINAZOLINE DERIVATIVE AS PHOSPHODIESTERASE INHIBITOR AND A PROCESS FOR PREPARING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2008-02-21 WO claimed
WO-2008020711-A1 QUINAZOLINE DERIVATIVE AS PHOSPHODIESTERASE INHIBITOR AND A PROCESS FOR PREPARING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2008-02-21 WO disclosed