Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 14/20 | 0.46 |
| ▸ | PRKDC | P78527 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.43 |
| ▸ | LDHB | P07195 | 2/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1167032 | 0.78 | GSK3B (0.39) | — | |
| SCHEMBL23389767 | 0.77 | ATR (0.57) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL23389810 | 0.76 | ATR (0.67) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL3460106 | 0.75 | ATR (0.67) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL16533813 | 0.75 | ATR (0.55) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL23419962 | 0.75 | ATR (0.69) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL16505267 | 0.75 | ATR (0.55) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL3462566 | 0.74 | ATR (0.66) | ATRPRKDCATM | |
| SCHEMBL3459928 | 0.73 | ATR (0.53) | ATRPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL3463062 | 0.73 | ATR (0.53) | ATRPRKDCPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008038010-A1 | PYRAZINE DERIVATIVES AND THEIR USE IN THERAPY | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |