Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 15/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727014 | 0.85 | PIK3CB (0.59) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4535546 | 0.81 | PIK3CB (0.47) | PIK3CBPIK3CAAKT1MTOR | |
| SCHEMBL4524096 | 0.81 | PIK3CB (0.68) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4523237 | 0.80 | PIK3CD (0.45) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL10125673 | 0.79 | PIK3CB (0.53) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL16308204 | 0.78 | PIK3CB (0.52) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4780048 | 0.78 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4462056 | 0.77 | PIK3CB (0.56) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL3586878 | 0.77 | PIK3CB (0.61) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4535561 | 0.77 | PIK3CB (0.52) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032077-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |