Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.59 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.59 |
| ▸ | BRD4 | O60885 | 5/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.43 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | NEK4 | P51957 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784001 | 0.88 | PLK1 (0.61) | PLK1PLK3BRD4ALKPSEN1 | |
| SCHEMBL4730833 | 0.88 | PLK1 (0.63) | PLK1PLK3BRD4ALKPSEN1 | |
| SCHEMBL4784233 | 0.87 | PLK1 (0.62) | PLK1PLK3BRD4ALKPSEN1 | |
| SCHEMBL4782049 | 0.86 | PLK1 (0.55) | PLK1PLK3BRD4MAPK7PLK2 | |
| SCHEMBL4782849 | 0.85 | PLK1 (0.60) | PLK1PLK3BRD4ALKPLK2 | |
| SCHEMBL4800861 | 0.85 | PLK1 (0.60) | PLK1PLK3BRD4ALKPSEN1 | |
| SCHEMBL4781788 | 0.85 | PLK1 (0.60) | PLK1PLK3BRD4ALKPSEN1 | |
| SCHEMBL4783604 | 0.85 | PLK1 (0.68) | PLK1PLK3BRD4ALKMAPK7 | |
| SCHEMBL4784197 | 0.84 | PLK1 (0.56) | PLK1PLK3BRD4MAPK7PLK2 | |
| SCHEMBL4784694 | 0.84 | PLK1 (0.59) | PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |