SCHEMBL4732037

SCHEMBL4732037

Cc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1NC(=O)c1ccc(=O)[nH]n1

nearest known ligand 0.64

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FASN P49327 20/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4733978 0.92 FASN (0.57) FASN
SCHEMBL4735394 0.85 FASN (0.66) FASN
SCHEMBL4786339 0.84 FASN (0.71) FASN
SCHEMBL4732219 0.83 FASN (0.73) FASN
SCHEMBL4784684 0.83 FASN (0.65) FASN
SCHEMBL4732775 0.83 FASN (0.78) FASN
SCHEMBL4736854 0.83 FASN (0.69) FASN
SCHEMBL4785694 0.82 FASN (0.67) FASN
SCHEMBL4734450 0.82 FASN (0.69) FASN
SCHEMBL4736922 0.82 FASN (0.71) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008059214-A1 BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-05-22 WO claimed