SCHEMBL4732489

SCHEMBL4732489

Cc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1NC(=O)Cc1cccnc1

nearest known ligand 0.64

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FASN P49327 20/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4785691 0.90 FASN (0.56) FASN
SCHEMBL4733592 0.90 FASN (0.64) FASN
SCHEMBL4735607 0.90 FASN (0.61) FASN
SCHEMBL4193603 0.89 FASN (0.62) FASN
SCHEMBL4734067 0.88 FASN (0.62) FASN
SCHEMBL4784630 0.88 FASN (0.53) FASN
SCHEMBL4785082 0.88 FASN (0.58) FASN
SCHEMBL4202858 0.88 FASN (0.61) FASN
SCHEMBL4735338 0.87 FASN (0.72) FASN
SCHEMBL4732219 0.82 FASN (0.73) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008059214-A1 BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-05-22 WO disclosed