Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4101640 | 0.93 | MEN1 (0.62) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL4101645 | 0.93 | MEN1 (0.62) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL18230266 | 0.86 | MEN1 (0.66) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL18230267 | 0.86 | MEN1 (0.66) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL6418180 | 0.86 | MEN1 (0.49) | MEN1KMT2AALDH1A1MAPTTHRB | |
| SCHEMBL6418177 | 0.86 | MEN1 (0.49) | MEN1KMT2AALDH1A1MAPTTHRB | |
| SCHEMBL2107778 | 0.84 | MEN1 (0.60) | MEN1KMT2AALDH1A1MAPTDRD2 | |
| SCHEMBL31234802 | 0.84 | MEN1 (0.60) | MEN1KMT2AALDH1A1MAPTDRD2 | |
| SCHEMBL2821240 | 0.84 | KMT2A (0.88) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL30737179 | 0.84 | KMT2A (0.88) | MEN1KMT2ACA1CA2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |