SCHEMBL4733649

SCHEMBL4733649

Cc1ccc(C(=O)N2CCC(c3ccc(Cl)c(Cl)c3)CC2)cc1NC(=O)c1ccc(N(C)C)nc1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FASN P49327 18/20 0.59
HTR1A P08908 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4735716 0.91 FASN (0.61) FASN
SCHEMBL4731958 0.90 FASN (0.72) FASN
SCHEMBL4733279 0.88 FASN (0.62) FASN
SCHEMBL4735650 0.86 FASN (0.61) FASN
SCHEMBL4735280 0.86 FASN (0.58) FASN
SCHEMBL4733976 0.86 FASN (0.53) FASN
SCHEMBL4734574 0.86 FASN (0.58) FASN
SCHEMBL4732466 0.86 FASN (0.75) FASN
SCHEMBL4733303 0.86 FASN (0.60) FASN
SCHEMBL4799372 0.85 FASN (0.49) FASNHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008059214-A1 BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-05-22 WO disclosed