Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828222 | 1.00 | PARP1 (0.60) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL828410 | 0.85 | PARP1 (0.61) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL2789377 | 0.80 | KDM4E (0.60) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL4260461 | 0.75 | KDM4E (0.57) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL3103147 | 0.75 | PARP1 (1.00) | PARP1 | |
| SCHEMBL1298127 | 0.74 | PARP1 (0.73) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL9725333 | 0.74 | DHODH (0.77) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL15808131 | 0.74 | KDM4E (0.56) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL8952887 | 0.72 | KDM4E (0.62) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL7863163 | 0.72 | PARP1 (0.63) | PARP1KDM4EHPGDDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899324-A2 | BENZIMIDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | Theravance, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006127815-A2 | BENZIMIDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2006-11-30 | — | — | WO | disclosed |