Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 10/20 | 0.48 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.48 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784490 | 0.89 | FASN (0.56) | FASNSFRP1SLC9A1PRSS12EGLN1 | |
| SCHEMBL4735650 | 0.89 | FASN (0.61) | FASNPROKR1 | |
| SCHEMBL4735674 | 0.84 | FASN (0.59) | FASNPROKR1 | |
| SCHEMBL4733303 | 0.83 | FASN (0.60) | FASNPROKR1EGLN1 | |
| SCHEMBL4786310 | 0.83 | FASN (0.61) | FASNPROKR1 | |
| SCHEMBL4735576 | 0.80 | FASN (0.60) | FASNEGLN1 | |
| SCHEMBL4735716 | 0.78 | FASN (0.61) | FASNPROKR1 | |
| SCHEMBL4733279 | 0.78 | FASN (0.62) | FASNPROKR1 | |
| SCHEMBL4784807 | 0.77 | FASN (0.70) | FASNPRSS12 | |
| SCHEMBL4734574 | 0.76 | FASN (0.58) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |