Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 14/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 12/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.67 |
| ▸ | CDK2 | P24941 | 7/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CDK1 | P06493 | 1/20 | 0.61 |
| ▸ | CDK4 | P11802 | 1/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.61 |
| ▸ | CCND1 | P24385 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473583 | 0.87 | MAPK8 (0.77) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL473585 | 0.87 | MAPK8 (0.77) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL4000541 | 0.87 | MAPK8 (0.76) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL4000544 | 0.87 | MAPK8 (0.76) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL4133952 | 0.84 | MAPK8 (0.72) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL473468 | 0.84 | MAPK8 (0.78) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL4004010 | 0.84 | MAPK8 (0.78) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL473602 | 0.83 | MAPK8 (0.80) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL473603 | 0.83 | MAPK8 (0.80) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL473522 | 0.82 | MAPK8 (0.68) | MAPK8MAPK9MAPK10CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066319-B1 | BENZOTRIAZOLE KINASE MODULATORS | HOFFMANN LA ROCHE (CH) | 2012-02-01 | — | — | EP | disclosed |