Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 4/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14370267 | 0.93 | NAMPT (0.48) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL8355568 | 0.92 | PDE4B (0.61) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL19103523 | 0.90 | NAMPT (0.52) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL19703149 | 0.90 | NAMPT (0.52) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL25202591 | 0.89 | NAMPT (0.51) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL4886160 | 0.89 | TACR3 (0.51) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL15862956 | 0.89 | NAMPT (0.51) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL31342575 | 0.89 | TACR3 (0.51) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL4846419 | 0.89 | MAPT (0.51) | NAMPTMAPTKDM4ETHRBSTS | |
| SCHEMBL30412116 | 0.89 | NAMPT (0.51) | NAMPTMAPTKDM4ETHRBSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |
| EP-0580398-B1 | Carbamoyl pyrrolidone derivatives for the treatment of depression and cerebrovascular disorders | SHIONOGI & CO (JP) | 1999-11-24 | — | — | EP | disclosed |
| US-5321035-A | Antiserotonin, antiischemic agents | SHIONOGI & CO., LTD. (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0580398-A1 | Carbamoyl pyrrolidone derivatives for the treatment of depression and cerebnovascular disorders | SHIONOGI & CO., LTD. (JP) | 1994-01-26 | — | — | EP | disclosed |