Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.83 |
| ▸ | TP53 | P04637 | 2/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | USP2 | O75604 | 1/20 | 0.83 |
| ▸ | HPGD | P15428 | 1/20 | 0.83 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | MAOB | P27338 | 8/20 | 0.63 |
| ▸ | STK17B | O94768 | 1/20 | 0.59 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737972 | 0.92 | MAPT (0.83) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| Sappanone A Dimethyl Ether SCHEMBL4734315 | 0.91 | MAPT (1.00) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| Sappanone A Dimethyl Ether SCHEMBL16636357 | 0.91 | MAPT (1.00) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| Sappanone A 7-Methyl Ether SCHEMBL14479894 | 0.86 | MAPT (1.00) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| SCHEMBL25502273 | 0.84 | MAPT (0.84) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| SCHEMBL14160753 | 0.84 | MAPT (0.84) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| Sappanone A Trimethyl Ether SCHEMBL25035400 | 0.83 | MAPT (1.00) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| Sappanone A Trimethyl Ether SCHEMBL30274257 | 0.83 | MAPT (1.00) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| Sappanone A Trimethyl Ether SCHEMBL14479888 | 0.83 | MAPT (1.00) | MAPTCYP3A4ALDH1A1TP53MAPK1 | |
| SCHEMBL5725448 | 0.83 | MAOB (0.67) | MAPTCYP3A4ALDH1A1TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067451-A1 | NOVEL 3-BENZYLIDINE AND 3-BENZYL SUBSTITUTED CHROMANONES | ITHERX PHARMACEUTICALS, INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008067451-A1 | NOVEL 3-BENZYLIDINE AND 3-BENZYL SUBSTITUTED CHROMANONES | ITHERX PHARMACEUTICALS, INC. (US) | 2008-06-05 | — | — | WO | disclosed |