Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30052313 | 0.82 | CDK1 (0.62) | CDK1CCNB1CCNE1CDK2EGFR | |
| SCHEMBL1672138 | 0.82 | CDK1 (0.62) | CDK1CCNB1CCNE1CDK2EGFR | |
| SCHEMBL5049212 | 0.81 | CDK1 (0.60) | CDK1CCNB1CCNE1CDK2EGFR | |
| SCHEMBL23885478 | 0.80 | CDK1 (0.44) | CDK1CCNB1CCNE1CDK2EGFR | |
| SCHEMBL30052639 | 0.80 | CDK1 (0.44) | CDK1CCNB1CCNE1CDK2EGFR | |
| SCHEMBL26628550 | 0.77 | PDE4A (0.63) | CDK1CCNB1CCNE1CDK2CYP2C19 | |
| SCHEMBL448173 | 0.75 | ADORA2A (0.40) | EGFRCSNK2A2CSNK2A1ADORA1ADORA2A | |
| SCHEMBL28685162 | 0.75 | ADORA2A (0.49) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL1673251 | 0.75 | EGFR (0.70) | EGFRADORA1ADORA2API4KAPI4K2B | |
| SCHEMBL12417532 | 0.74 | CDK1 (0.60) | CDK1CCNB1CCNE1CDK2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238003-B2 | Extended or continuous wear silicone hydrogel contact lenses for the extended release of comfort molecules | AUBURN UNIVERSITY (US) | 2016-01-19 | — | — | US | disclosed |
| US-20130195952-A1 | EXTENDED OR CONTINUOUS WEAR SILICONE HYDROGEL CONTACT LENSES FOR THE EXTENDED RELEASE OF COMFORT MOLECULES | AUBURN UNIVERSITY (US) | 2013-08-01 | — | — | US | disclosed |
| US-8388995-B1 | Controlled and extended delivery of hyaluronic acid and comfort molecules via a contact lens platform | AUBURN UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |
| US-8349352-B2 | for delivering a drug through contact with an eye; treatment of large animals, such as horses | AUBURN UNIVERSITY (US) | 2013-01-08 | — | — | US | disclosed |
| US-20080124378-A1 | Therapeutic contact lenses with anti-fungal delivery | AUBURN UNIVERSITY | 2008-05-29 | — | — | US | disclosed |
| WO-2008060574-A2 | THERAPEUTIC CONTACT LENSES WITH ANTI-FUNGAL DELIVERY | AUBURN UNIVERSITY (US) | 2008-05-22 | — | — | WO | disclosed |