Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 15/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737564 | 0.99 | CHRM3 (0.97) | CHRM3CHRM1MLNRCHRM2HTR2A | |
| SCHEMBL4735223 | 0.99 | CHRM3 (0.97) | CHRM3CHRM1MLNRCHRM2HTR2A | |
| SCHEMBL4736198 | 0.90 | CHRM3 (0.82) | CHRM3CHRM1MLNRCHRM2HTR2A | |
| SCHEMBL4738320 | 0.89 | CHRM3 (0.80) | CHRM3CHRM1MLNRCHRM2HTR2A | |
| SCHEMBL4740203 | 0.87 | CHRM3 (0.77) | CHRM3CHRM1MLNRCHRM2HTR2A | |
| SCHEMBL4736316 | 0.86 | CHRM3 (0.76) | CHRM3CHRM1MLNRCHRM2HTR2A | |
| SCHEMBL14162144 | 0.85 | CHRM3 (1.00) | CHRM3 | |
| Iodide SCHEMBL4784581 | 0.84 | CHRM3 (0.98) | CHRM3 | |
| SCHEMBL14162443 | 0.84 | CHRM3 (1.00) | CHRM3 | |
| SCHEMBL14162201 | 0.84 | CHRM3 (1.00) | CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075006-A1 | PIPERLDINUM COMPOUNDS FOR TREATMENT OF OBSTRUCTIVE PULMONARY DISEASES ( COPD) | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008075006-A1 | PIPERLDINUM COMPOUNDS FOR TREATMENT OF OBSTRUCTIVE PULMONARY DISEASES ( COPD) | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |