Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.51 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14084153 | 0.99 | HRH4 (0.52) | HRH3ADORA1ADORA2AHRH4HRH1 | |
| SCHEMBL14084147 | 0.97 | HRH4 (0.52) | HRH3ADORA1ADORA2AHRH4HRH1 | |
| SCHEMBL14084160 | 0.96 | HRH4 (0.51) | HRH3ADORA1ADORA2AHRH4HRH1 | |
| SCHEMBL14084159 | 0.93 | HRH4 (0.54) | HRH3ADORA1ADORA2AHRH4HRH1 | |
| SCHEMBL14084158 | 0.90 | HRH4 (0.54) | HRH3ADORA1ADORA2AHRH4HRH1 | |
| SCHEMBL14084161 | 0.78 | HRH4 (0.49) | HRH3HRH4HRH1HRH2ACP1 | |
| SCHEMBL14084166 | 0.78 | HRH4 (0.48) | HRH3ADORA1ADORA2AHRH4HRH1 | |
| SCHEMBL14084176 | 0.78 | HRH3 (0.50) | HRH3ADORA1ADORA2AHRH4HRH1 | |
| SCHEMBL14084182 | 0.78 | HRH4 (0.47) | HRH3ADORA1ADORA2AHRH4HRH1 | |
| SCHEMBL14084126 | 0.77 | HRH4 (0.52) | HRH3HRH4HRH1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060766-A2 | HISTAMINE H4 RECEPTOR LIGANDS FOR USE IN PAIN TREATMENT | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |